The American Institute for Cancer Research has estimated that about 45% of colorectal cancer cases could be prevented through a healthy diet, physical activity, and maintaining a healthy weight! This provides tremendous incentive for us to take control of our lifestyle habits and make a positive change.
What is immediately apparent from these numbers is that Cologuard rarely misses cancer. However, if we count polyps as a significant finding, there are plenty of false-positive results (45%) and plenty of false-negatives too (34%). So is Cologuard a good test overall?
In keeping with the theme of women being smarter than men, the authors found no association between the happiness of the marriage or the degree of support from their husbands for women who chose to get a colonoscopy. Basically, women are just better at taking care of themselves independently without the need for their husbands approval, input, or coercion.
If you notice, the basic idea here is pretty simple. According to the guidelines, there are really only a few options for follow-up intervals for colonoscopy: 10 years (negative exam), 5 years (low risk polyps), and 3 years (high risk polyps). Less than 3 years is only recommended in the truly unusual case of a large polyp burden or invasive cancer in a polyp. And that's it.
I thought it would be a good time to show a real-life example of colorectal cancer prevention in action. Let's pretend that you are a friendly neighborhood gastroenterologist, just minding your own business and doing a screening colonoscopy on a patient.
It is sometimes an awkward conversation to have, but the truth is that at a certain age, we eventually stop checking people for things that may cause them future harm.
Clearly, the screening guidelines recommend repeating a negative colonoscopy in ten years. Now what if I told you that many (if not most) practicing gastroenterologists recommend repeating the test in five years, not ten?
If there is one take-home message for colorectal cancer screening it is this: Start screening most people at age 50. Colonoscopy is the preferred screening test.
Here in Long Island, NY where I practice, it seems to be the norm to have a precolonoscopy visit. This visit serves several important purposes in my mind: I can meet the patient, take a history, and make sure they actually need a screening colonoscopy. I can answer all of the above questions in more detail than the primary doctor can. I also get to give them my basic talk about the purpose of a colonoscopy, how and why we remove polyps, the importance of good bowel prep and how to do it, and the small associated risks of a colonoscopy. We can talk about what to do with medications, and where to arrive on the day of the test, and parking, and all those seemingly small details that can make a patient stressed-out about the test for no good reason.
I was surprised when the pathologist called me a few days later about the patient, since pathologists usually only call when a result is malignant or unusual. This "polyp" which I estimated to be about 15-mm in greatest diameter was a serrated adenoma (not a surprise) but also contained an 8-mm focus of adenocarcinoma. Luckily, the carcinoma portion of the polyp was completely resected with clear margins on all sides, however this polyp was truly an early-stage colon cancer!
So what does this all mean? Should you never eat red meat? Is this the end of the bacon cheeseburger? Of course not! When faced with information like this we really need to step back and look at the big picture. How much do you enjoy eating a juicy steak or a grilled hot dog on a warm summer day? What is the purpose of life? What is the lifetime mortality of someone who never eats red meat? (Hint: it's 100%.) Let's not forget that red meat is also an excellent source of protein, iron, B vitamins, and zinc...oh, and it tastes pretty good too!
So what are some take home points about meat intake in Crohn's disease? Red meat (beef, lamb, pork [yes pork too!]) can be though of as pro-inflammatory foods. It is reasonable to limit consumption of red meat to once or twice per week at most. Fish is probably a good alternative to red meat. These recommendations are based on very limited, low-quality data. Sometimes this is better than no data at all!
For many years, the effect of NSAIDs on preventing colon cancer has been described. There are numerous studies showing a small but mostly consistent decrease in both the development of polyps, and the development of colorectal cancer with chronic NSAID use. However, thus far there has not been a recommendation to take NSAIDs specifically with the goal of reducing the development of colon cancer, since the risk of chronic NSAID use is thought to outweigh any benefit in cancer prevention.
Of the cancers that both men and women can get, colon cancer is the second leading cause of cancer death in the Unites States. Colonoscopy, when performed by an expert with an adequate adenoma detection rate, has been shown to reduce the risk of developing colorectal cancer. For most people, routine screening colonoscopy is recommended starting at … Read more
Occult gastrointestinal bleeding simply means that there is blood loss into the GI tract that cannot be seen with the naked eye (as opposed to overt GI bleeding, where blood is seen). Typically, patients with occult GI bleeding have slowly progressive anemia due to slow chronic blood loss. There are a variety of causes of … Read more